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DeCS
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Descriptor English:
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Integrin alpha Chains
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Descriptor Spanish:
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Cadenas alfa de Integrinas
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Descriptor Portuguese:
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Cadeias alfa de Integrinas
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Synonyms English:
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Integrin alpha Subunits
Integrins, alpha
alpha Chains, Integrin
alpha Integrins
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Tree Number:
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D12.776.543.750.705.408.100
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Definition English:
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The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4. |
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History Note English:
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2003
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Allowable Qualifiers English:
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Record Number:
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37482
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Unique Identifier:
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D039001
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Occurrence in VHL:
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Similar:
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DeCS
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